TK1 and ADAMTS10

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		TK1	ADAMTS10
Description		thymidine kinase 1	ADAM metallopeptidase with thrombospondin type 1 motif 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Molecular_function Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Phosphorylation Thymidine Metabolic Process Protein Homotetramerization DNA Biosynthetic Process	Proteolysis Biological_process Extracellular Matrix Organization
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Body size at age 10 ( 32376654) Carpal tunnel syndrome ( 30833571) Height ( 28552196 20881960 25282103 18391951) Hip circumference adjusted for BMI ( 34021172) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Resting metabolic rate ( 28476931) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		163 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DCAF7 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	7 interacting genes: ANXA7 CDKN1A HMGCL LAMTOR3 PCYT2 SMN1 TK1
Entrez ID		7083	81794
HPRD ID		01771	07470
Ensembl ID		ENSG00000167900	ENSG00000142303
Uniprot IDs		A0A384MDV9 K7ES52 P04183	A0A0A0MQW6 Q59FE5 Q6ZN14 Q9H324
PDB IDs		1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?
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