TIMP3 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 7782289)
57

Data Source:
HPRD (in vitro)

		TIMP3	MMP2
Description		TIMP metallopeptidase inhibitor 3	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Visual Perception Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Platelet degranulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Pimagedine	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease progression score ( 29860282) Blood protein levels ( 28240269) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7078	4313
HPRD ID		01785	00386
Ensembl ID		ENSG00000100234	ENSG00000087245
Uniprot IDs		P35625	A0A024R6R4 P08253
PDB IDs		3CKI	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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