TIMP1 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 12475252)
19

Data Source:
HPRD (in vitro)

		TIMP1	MMP2
Description		TIMP metallopeptidase inhibitor 1	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Cell Activation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Aging Positive Regulation Of Cell Population Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases
GWAS			Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7076	4313
HPRD ID		02371	00386
Ensembl ID		ENSG00000102265	ENSG00000087245
Uniprot IDs		B4DJK3 P01033 Q6FGX5	A0A024R6R4 P08253
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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