TGFB2 and VTN

Number of citations of the paper that reports this interaction (PubMedID 11796824)
12

Data Source:
HPRD (in vitro)

		TGFB2	VTN
Description		transforming growth factor beta 2	vitronectin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Platelet Alpha Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Polysaccharide Binding
	Biological Process	Cell Morphogenesis Skeletal System Development Eye Development Response To Hypoxia Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Hair Follicle Development Heart Morphogenesis Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Heart Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Neural Retina Development Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Cell Death Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Male Gonad Development Response To Xenobiotic Stimulus Response To Wounding Embryo Development Ending In Birth Or Egg Hatching Cardioblast Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Ascending Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Dopamine Biosynthetic Process Odontogenesis Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Negative Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Development Generation Of Neurons Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Regulation Of Cell Cycle Positive Regulation Of Cell Division Regulation Of Timing Of Catagen Positive Regulation Of Timing Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Uterus Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Secondary Palate Development Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Complement-dependent Cytotoxicity Substantia Propria Of Cornea Development Cranial Skeletal System Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways		Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs			Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density (hip) ( 30172743) Central corneal thickness ( 32528159 29760442) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease (severe) ( 24621683) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Intraocular pressure ( 29617998) Local histogram emphysema pattern ( 25006744) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)
Interacting Genes		17 interacting genes: APP BMP2 CCN2 DCN ENG FMOD KMT2A LTBP3 MARK1 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	47 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		7042	7448
HPRD ID		01828	01902
Ensembl ID		ENSG00000092969	ENSG00000109072
Uniprot IDs		P61812 Q59EG9	D9ZGG2 P04004
PDB IDs		1TFG 2TGI 4KXZ 5TX4 5TY4 6I9J	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
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