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TGFB1 and YWHAE
Number of citations of the paper that reports this interaction (PubMedID
11172812
)
12
Data Source:
HPRD
(in vivo)
TGFB1
YWHAE
Description
transforming growth factor beta 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Plasma Membrane
Microvillus
Cell Surface
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Blood Microparticle
Nucleus
Cytoplasm
Cytosol
Kinesin Complex
Plasma Membrane
Focal Adhesion
Membrane
Melanosome
Extracellular Exosome
Central Region Of Growth Cone
Glutamatergic Synapse
Molecular Function
Antigen Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Enzyme Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
RNA Binding
Calcium Channel Regulator Activity
Protein Binding
Potassium Channel Regulator Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Transmembrane Transporter Binding
Cadherin Binding
Protein Heterodimerization Activity
Phosphoserine Residue Binding
Phosphoprotein Binding
Scaffold Protein Binding
Biological Process
MAPK Cascade
Vasculogenesis
Epithelial To Mesenchymal Transition
Neural Tube Closure
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Chondrocyte Differentiation
Hematopoietic Progenitor Cell Differentiation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Protein Phosphorylation
Protein Export From Nucleus
ATP Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Salivary Gland Morphogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Wounding
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Macrophage Cytokine Production
Positive Regulation Of Microglia Differentiation
Regulation Of Striated Muscle Tissue Development
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Neural Tube Development
Negative Regulation Of Cell-cell Adhesion
Hyaluronan Catabolic Process
Negative Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein-containing Complex Assembly
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Response To Estradiol
Response To Progesterone
Positive Regulation Of Interleukin-17 Production
Receptor Catabolic Process
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Dephosphorylation
Regulation Of Cell Population Proliferation
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Vascular Permeability
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Ossification Involved In Bone Remodeling
Cell-cell Junction Organization
Negative Regulation Of Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cytolysis
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgA Isotypes
Lymph Node Development
Negative Regulation Of Skeletal Muscle Tissue Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Chemotaxis
Regulation Of Binding
Regulation Of DNA Binding
Regulation Of Cell Cycle
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Blood Vessel Remodeling
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Negative Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Biomineral Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Organic Cyclic Compound
Cellular Response To Transforming Growth Factor Beta Stimulus
Extracellular Matrix Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of NAD+ ADP-ribosyltransferase Activity
Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Receptor Signaling Pathway Via STAT
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development
Embryonic Liver Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Cardiac Muscle Cell Differentiation
MAPK Cascade
Regulation Of Heart Rate By Hormone
Signal Transduction
Regulation Of Mitotic Cell Cycle
Substantia Nigra Development
Protein Localization To Nucleus
Cellular Response To Heat
Cellular Protein Localization
Intracellular Signal Transduction
Positive Regulation Of Protein Export From Nucleus
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Membrane Repolarization
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Peptidyl-serine Dephosphorylation
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways
Platelet degranulation
Influenza Virus Induced Apoptosis
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
UCH proteinases
Interleukin-4 and Interleukin-13 signaling
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Signaling by Hippo
NADE modulates death signalling
Regulation of PLK1 Activity at G2/M Transition
Regulation of HSF1-mediated heat shock response
HSF1 activation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RAB GEFs exchange GTP for GDP on RABs
Drugs
Hyaluronidase (ovine)
Terazosin
Hyaluronidase (human recombinant)
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Hyaluronidase
Fusicoccin
Phenethyl Isothiocyanate
Diseases
GWAS
Alanine aminotransferase levels (
34315874
)
Aspartate aminotransferase levels (
34315874
)
Colorectal cancer (
27145994
24836286
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Hematuria (
30476138
)
Hematuria (mild) (
30476138
)
Hematuria (moderate to severe) (
30476138
)
Platelet count (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Pulse pressure (
30578418
)
Type 2 diabetes (
31049640
)
Atrial fibrillation (
30061737
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Left ventricular mass to end-diastolic volume ratio (MTAG) (
33495596
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nicotine dependence symptom count (
25555482
)
Reaction time (
29844566
)
Schizophrenia (
28991256
30285260
)
Interacting Genes
95 interacting genes:
ACVRL1
ADAMTSL4
AGR3
ANGPTL4
APC
APP
AURKA
AXIN2
BCAS3
BCL10
BGN
BLID
BMP2
BMP3
BMPR1A
BUB1
CATSPER1
CCDC33
CCL3
CCL5
CCN2
CDKN2A
COL2A1
CST6
CYSRT1
DAXX
DCN
DIRAS3
DLC1
DPT
EGFR
EIF3I
ENG
ERBB2
FBXW7
FCHO1
FCN1
FKBP1A
FMOD
FNTA
GREB1
HOXA1
HOXC6
ITGAV
ITGB6
ITGB8
KLK5
KLK7
KLK9
KRTAP1-1
KRTAP1-3
KRTAP10-8
KRTAP4-11
LAMTOR5
LCE1A
LCE1C
LCE1D
LCE2B
LCE2C
LCE3A
LCE3B
LCE3D
LPXN
LTBP1
LTBP3
LTBP4
MCC
MEOX2
MLH3
MMP2
MTA3
NSD3
P4HB
PDGFRL
PDLIM2
POU4F2
PRSS50
PSMC3IP
PZP
RAPGEF3
SCGB3A1
SDC2
SNAI1
SPARC
ST14
TGFB2
TGFBR1
TGFBR2
TGFBR3
THBS1
THRSP
TLR2
VASN
VTN
YWHAE
148 interacting genes:
-
ABL1
ACD
AKAP13
AKAP9
ANKHD1-EIF4EBP3
ANKZF1
ARHGEF2
ARHGEF28
ATP6V0B
ATXN1
BAD
BCR
BEX3
CALM1
CAP2
CASK
CASP3
CCDC125
CCR9
CDC25A
CDC25B
CDK11B
CDK14
CDK16
CDKN1B
CEP131
CEP95
CGNL1
CHAF1A
CHST11
CYSLTR2
DDX54
DISC1
DYRK1A
ENKD1
EXO1
FAM13B
FAM53C
FGF12
FHL1
FTH1
GAPDH
GPRIN2
GRAP2
GSTA1
GSTM3
GTF2B
HDAC4
HDAC5
HIVEP2
HNRNPC
HSF1
HSP90AA1
HSPB1
IGF1R
IL7R
ING1
IRAG2
IRS1
IRS2
ITPRID2
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KIAA0232
KIF1C
KLC4
KRT18
LCP2
MAGEB4
MAP3K1
MAP3K10
MAP3K2
MAP3K3
MAP3K5
MAPK7
MCM10
MDM4
METAP2
MSL2
MST1R
MT-CO2
MYH10
NAF1
NCOR2
NDEL1
NIN
PAPOLA
PARD3B
PCM1
PIMREG
PNLIP
POT1
PRC1
PRDX6
PRKCG
RAB11FIP2
RAF1
RAP1GAP2
RASAL3
RASGRF1
RBIS
RBM14
REM1
RGS3
RIN1
RPA2
RPGR
RXFP3
SAMSN1
SH3BP4
SLC8A1
SLC8A2
SLC8A3
SMAGP
SNAPIN
SNCA
SNF8
SORBS2
SRC
SYN2
TAF7
TAFAZZIN
TBC1D3F
TBP
TCEANC
TFDP2
TGFB1
TLK1
TNFAIP3
TOP2A
TSC1
TSC2
UBE3A
USP43
VIM
WNK1
WWTR1
YWHAB
YWHAG
YWHAH
YWHAQ
YWHAZ
ZC3HC1
ZNF839
Entrez ID
7040
7531
HPRD ID
01821
05457
Ensembl ID
ENSG00000105329
ENSG00000108953
Uniprot IDs
A0A499FJK2
P01137
P62258
V9HW98
PDB IDs
1KLA
1KLC
1KLD
3KFD
4KV5
5FFO
5VQP
6OM2
6P7J
2BR9
3UAL
3UBW
6EIH
Enriched GO Terms of Interacting Partners
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