NR2F2 and TRIP4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		NR2F2	TRIP4
Description		nuclear receptor subfamily 2 group F member 2	thyroid hormone receptor interactor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Nuclear Body Neuromuscular Junction Protein-containing Complex Activating Signal Cointegrator 1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Protein Kinase Binding Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Female Gonad Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Anatomical Structure Development Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment	Regulation Of Transcription, DNA-templated Intracellular Estrogen Receptor Signaling Pathway Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Rescue Of Stalled Ribosome Toxin Transport Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Alzheimer's disease (late onset) ( 24162737) Neuroticism ( 29255261)
Interacting Genes		21 interacting genes: BCL11A BCL11B BIK CHD2 EP300 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 RLBP1 SETD7 SQSTM1 SYCP3 TENT5A TRIM24 TRIP4	23 interacting genes: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SRF TBP THRB UBC XBP1
Entrez ID		7026	9325
HPRD ID		00139	05140
Ensembl ID		ENSG00000185551	ENSG00000103671
Uniprot IDs		F1D8R0 P24468	Q15650
PDB IDs		3CJW	2E5O
Enriched GO Terms of Interacting Partners?
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