TERT and DYRK2

Number of citations of the paper that reports this interaction (PubMedID 23362280)
30

Data Source:
BioGRID (enzymatic study)

		TERT	DYRK2
Description		telomerase reverse transcriptase	dual specificity tyrosine phosphorylation regulated kinase 2
Image
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Protein Serine Kinase Activity
	Biological Process	Telomere Maintenance Transcription, RNA-templated RNA-dependent DNA Biosynthetic Process Telomere Maintenance Via Telomerase Mitochondrion Organization Negative Regulation Of Gene Expression DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Regulation Of Protein Stability Positive Regulation Of Protein Binding Positive Regulation Of Hair Cycle Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Glucose Import Response To Cadmium Ion Positive Regulation Of Nitric-oxide Synthase Activity Double-stranded RNA Biosynthetic Process Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Transdifferentiation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex	Regulation of TP53 Activity through Phosphorylation
Drugs		Zidovudine Grn163l Tertomotide
Diseases
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 31174203 33549134 19151717 24403052 25855136) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 24163127 20972438) Breast cancer ( 22037553 29059683 23535729 23535733 27117709 28171663) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 28165464 26956414) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21827660 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 31710517 18835860) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 20700438 28604730 19836008 22797724 20871597 27393504) Lung cancer ( 31577861 21725308 23143601 27393504 18978790) Lung cancer in never smokers ( 31009812 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 27436580 26545403) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 29422604 27579533 25086665) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 31562322 21743467 25939597) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 29403010 32888494 20139978 27863252) Serum prostate-specific antigen levels ( 21160077) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 29403010 32888494 27863252)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)
Interacting Genes		89 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B ATPAF2 BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 EXOC3 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HMGB2 HSP90AA1 HSPA4 ICE1 IFT57 IREB2 IRS1 MAP2K3 MAP2K5 MAP3K5 MCRS1 MDM2 MET MTOR MYC NCL NDUFS6 NF2 NSD3 PABPC1 PBK PDCD6 PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 PTMA RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		7015	8445
HPRD ID		01754	04606
Ensembl ID		ENSG00000164362	ENSG00000127334
Uniprot IDs		O14746	Q92630
PDB IDs		2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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