TEK and ANGPT2

Number of citations of the paper that reports this interaction (PubMedID 9204896)
782

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		TEK	ANGPT2
Description		TEK receptor tyrosine kinase	angiopoietin 2
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Cytoplasm Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Centriolar Satellite Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Projection Collagen-containing Extracellular Matrix
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Growth Factor Binding Signaling Receptor Activity Identical Protein Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Heart Development Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Response To Radiation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Organic Cyclic Compound Response To Activity Negative Regulation Of Angiogenesis Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Negative Regulation Of Positive Chemotaxis Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Tie2 Signaling
Drugs		Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Fostamatinib Ripretinib	Faricimab
Diseases
GWAS		Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Intraocular pressure ( 29617998 29785010 30054594) Metabolite levels ( 23823483) Response to cytidine analogues (gemcitabine) ( 24483146)
Interacting Genes		25 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2	6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK
Entrez ID		7010	285
HPRD ID		02571	03563
Ensembl ID		ENSG00000120156	ENSG00000091879
Uniprot IDs		Q02763 Q59HG2	O15123
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE	1Z3S 1Z3U 2GY7 4JZC 4ZFG
Enriched GO Terms of Interacting Partners?
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