ACTC1 and WIPF1

Number of citations of the paper that reports this interaction (PubMedID 12029088)
24

Data Source:
HPRD (in vivo)

		ACTC1	WIPF1
Description		actin alpha cardiac muscle 1	WAS/WASL interacting protein family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Ruffle Cytosol Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle
	Molecular Function	Microfilament Motor Activity ATP Binding Myosin Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Actin Polymerization Or Depolymerization Actin Filament-based Movement Protein-containing Complex Assembly
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Atrial fibrillation ( 30061737 29892015) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	27 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CRKL CTTN FASTK GRB2 HCK HLCS HOMER3 ITSN2 NCK1 NCK2 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70
Entrez ID		70	7456
HPRD ID		00015	03835
Ensembl ID		ENSG00000159251	ENSG00000115935
Uniprot IDs		B3KPP5 P68032	A0A140VJZ9 O43516 Q2YDC4
PDB IDs			2A41
Enriched GO Terms of Interacting Partners?
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