BUB1 and AP4B1

Number of citations of the paper that reports this interaction (PubMedID 12419313)
12

Data Source:
HPRD (two hybrid)

		BUB1	AP4B1
Description		BUB1 mitotic checkpoint serine/threonine kinase	adaptor related protein complex 4 subunit beta 1
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GO Annotations	Cellular Component	Kinetochore Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Trans-Golgi Network Cytosol Extrinsic Component Of Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding Clathrin Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Signaling Mitotic Spindle Assembly Checkpoint Signaling Cell Population Proliferation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation	Protein Targeting Protein Localization Vesicle-mediated Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		63 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 XPA ZNF189 ZNF510	8 interacting genes: AP4E1 AP4M1 BMP10 BUB1 BUB1B TEPSIN ZBTB14 ZNF576
Entrez ID		699	10717
HPRD ID		03907	06259
Ensembl ID		ENSG00000169679	ENSG00000134262
Uniprot IDs		B4DYG2 O43683	A0A024R0J5 B1ALD0 B3KSJ4 B4DTG3 Q9Y6B7
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B	2MJ7
Enriched GO Terms of Interacting Partners?
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