TCEA2 and DES

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TCEA2	DES
Description		transcription elongation factor A2	desmin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Transcription Elongation Factor Complex	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated DNA-templated Transcription, Elongation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription By RNA Polymerase II	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels ( 34315874) Anxiety ( 31906708) Aspartate aminotransferase levels ( 34315874) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil counts ( 32888494) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Systolic blood pressure ( 27841878) Triglyceride levels ( 29083408) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)
Interacting Genes		133 interacting genes: ADAMTSL4 AGR2 AGTRAP AKT1S1 ALAS1 AMOTL2 APP ARMC10 AXIN2 BACH2 BHLHB9 BICD2 BOLL BRCA1 BTBD6 CAMKV CBY2 CCDC136 CCDC157 CCSER2 CDK11B CENPT CEP44 CEP76 CMTM4 CMTM6 CNTROB COX20 CYSRT1 DAB1 DCAF10 DES DHRS2 DNAJB9 DVL3 EAF1 EAF2 ERBB3 EXOSC8 FADD FAM9B FBF1 FCHO1 FXR1 GAS8 GIGYF1 GOLGA2 GPKOW GRIPAP1 GTF2B HES7 HIGD1C HIP1 HMBOX1 HOMEZ HSF2BP IKZF1 IKZF4 KCNF1 KCTD10 KCTD7 KIAA1958 KRT40 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP5-9 KXD1 LIMS1 LMNA LRRK2 LZTS1 LZTS2 MAGEA11 MARK3 MCC MCM2 MDK MEOX2 MID2 MKRN3 MSANTD4 MTUS2 NAB2 NECAB1 NECAB2 OSBPL3 PIBF1 PICK1 PIH1D2 PNMA1 PNMA5 POU6F2 PRPH RBPMS RETREG3 RPA1 SCYL1 SH3GL2 SSC5D STAC3 STX11 SYNE4 TARBP2 TAX1BP1 TAX1BP3 TBC1D1 TCF4 TEPSIN TFCP2 THAP1 TMEM71 TNIP1 TOX2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM38 TRIM41 TRIM54 TSGA10 USP54 VIM WDR47 ZBTB22 ZBTB43 ZBTB8A ZBTB9 ZKSCAN8 ZNF526 ZRANB1	62 interacting genes: ATIC AURKB B4GALT2 BAG5 BRCA1 C1orf216 CAPN1 CLIP4 CRYAB CT55 CWF19L2 DDX10 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 KRT75 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I VIM YES1 ZMYM5
Entrez ID		6919	1674
HPRD ID		16069	00514
Ensembl ID		ENSG00000171703	ENSG00000175084
Uniprot IDs		Q15560 Q6IB64	P17661 Q53SB5
PDB IDs		2LW4
Enriched GO Terms of Interacting Partners?
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