TBP and NCOA1

Number of citations of the paper that reports this interaction (PubMedID 8754792)
19

Data Source:
HPRD (in vitro)

		TBP	NCOA1
Description		TATA-box binding protein	nuclear receptor coactivator 1
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Protein-containing Complex Transcription Preinitiation Complex	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Neuron Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding General Transcription Initiation Factor Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Progesterone Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis Positive Regulation Of Transcription, DNA-templated RNA Polymerase II Preinitiation Complex Assembly	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Thyroid Hormone Mediated Signaling Pathway Lactation Male Gonad Development Cerebellum Development Hippocampus Development Hypothalamus Development Cerebral Cortex Development Response To Estradiol Response To Retinoic Acid Response To Progesterone Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Histone H4 Acetylation Estrous Cycle Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior Labyrinthine Layer Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cellular Response To Drug
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling
Drugs			Genistein Corticosterone Prinaberel ERB-196 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL TO-901317 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE GW-590735 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 3,20-Pregnanedione Indeglitazar (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myristic acid 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Aleglitazar
Diseases
GWAS		Type 1 diabetes ( 21980299)	Asthma ( 29273806) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chromium levels ( 26025379) Cognitive function ( 28093568) Diffuse large B cell lymphoma ( 25261932) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		124 interacting genes: ABT1 AHR AR ATF4 BCL3 BRD2 BRF1 BRF2 BTAF1 CAND2 CEP43 CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CUEDC2 CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR2A POLR3F POU2F1 POU2F2 POU3F2 PSMC2 PSME3 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76	90 interacting genes: AHR ANKRD11 AR ARID1A ARNT BCL3 CARM1 CCND1 CHMP2A CIITA COPS5 CPS1 CREBBP CXADR CYB561 DDX17 DDX5 EP300 ESR1 ESR2 ESRRA ESRRG FOS FOXA2 FOXO1 GTF2B HADHA HIF1A HNF1A HNF4A HNF4G JUN KANK2 KAT2B MAPK1 NCOR1 NFKB1 NKX2-1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR5A1 NR5A2 NR6A1 PAGR1 PGR PPARA PPARD PPARG PPARGC1A PPM1B PPP1CB PRMT1 PRMT2 PSMB9 RARA RARB RARG RORA RORB RXRA RXRB SLC28A2 SMARCC1 SMARCE1 SNW1 SRD5A2 SRF STAT3 STAT6 SUMO1 TBP TEAD1 TEAD2 THRA THRB TP53 TRIM27 TRIP4 VDR YWHAH YWHAQ ZNF512
Entrez ID		6908	8648
HPRD ID		02511	04070
Ensembl ID		ENSG00000112592	ENSG00000084676
Uniprot IDs		P20226 Q32MN7	Q15788
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L	1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2NPA 2NV7 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3GYT 3GYU 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3P88 3P89 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H 4HEE 4J5X 4JYG 4JYH 4JYI 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4RUJ 4RUP 4TUZ 4TV1 4UDA 4UDB 4Y29 5A86 5AVI 5AVL 5AZT 5DSH 5DV3 5DV6 5DV8 5DVC 5DWL 5E7V 5GTN 5GTO 5GTP 5HJS 5JI0 5JMM 5L7E 5L7G 5L7H 5MWP 5MWY 5MX7 5NKY 5NMA 5NMB 5NWM 5OW7 5OW9 5OWD 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5X0R 5X8U 5X8W 5Y44 5YCN 5YCP 5YP6 6A5W 6A5X 6A5Y 6A5Z 6A60 6BNS 6E3G 6FO7 6FO8 6FO9 6FOB 6FOD 6GEV 6GG8 6HTY 6ICJ 6IJR 6IJS 6ILQ 6ITM 6JNR 6JQ7 6KTM 6KTN 6L96 6NX1 6P9F 6SSQ 6T2M 6TFI 6U25 6W9H 6W9I 6XP9 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4 7JYM 7KXD 7KXE 7KXF
Enriched GO Terms of Interacting Partners?
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