TAP1 and HLA-F

Number of citations of the paper that reports this interaction (PubMedID 11169396)
48

Data Source:
HPRD (in vivo)

		TAP1	HLA-F
Description		transporter 1, ATP binding cassette subfamily B member	major histocompatibility complex, class I, F
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex	Golgi Membrane Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ADP Binding Metal Ion Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Neuron Death
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)	Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)
Interacting Genes		27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35C2 SSMEM1 TAP2 TAPBP TDP2 TMEM14B	5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1
Entrez ID		6890	3134
HPRD ID		01359	00884
Ensembl ID		ENSG00000168394	ENSG00000204642
Uniprot IDs		A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3	P30511 Q5JZ47 Q5JZ48
PDB IDs		1JJ7 5U1D	5IUE 5KNM
Enriched GO Terms of Interacting Partners?
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