ABCC8 and ENSA

Number of citations of the paper that reports this interaction (PubMedID 9653196)
15

Data Source:
HPRD (in vivo)

		ABCC8	ENSA
Description		ATP binding cassette subfamily C member 8	endosulfine alpha
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Sarcolemma	Nucleoplasm Cytoplasm
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Transmembrane Transporter Binding ABC-type Transporter Activity	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Cellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Wound Healing Negative Regulation Of Neuroblast Migration Cellular Response To Organic Substance Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Voltage-gated Potassium Channel Activity Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Nutrient Response To Glucose Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Catalytic Activity Regulation Of Insulin Secretion Cell Division
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases
GWAS		Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)	Albumin-globulin ratio ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Mean corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Neutrophil percentage of granulocytes ( 27863252) Non-albumin protein levels ( 29403010) Pericardial adipose tissue adjusted for height and weight ( 27918534) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	12 interacting genes: ABCC8 ACD ARIH2 DNMT1 ENO2 GORASP1 KCTD15 POT1 PSEN1 RAP2A SNCA SRPK2
Entrez ID		6833	2029
HPRD ID		02741	11927
Ensembl ID		ENSG00000006071	ENSG00000143420
Uniprot IDs		Q09428	O43768
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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