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STAT5B and CHAF1A
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
STAT5B
CHAF1A
Description
signal transducer and activator of transcription 5B
chromatin assembly factor 1 subunit A
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatin
Nucleus
Protein-containing Complex
CAF-1 Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Dimerization Activity
Chromatin Binding
Protein Binding
Identical Protein Binding
Unfolded Protein Binding
Chromo Shadow Domain Binding
Biological Process
Luteinization
Natural Killer Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
DNA Replication
DNA Repair
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
Cell Cycle
Chromatin Assembly
Pathways
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Dasatinib
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
34103634
32296059
)
Asthma (childhood onset) (
31036433
)
Body shape index (
34021172
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
27569725
28067908
23128233
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Interacting Genes
62 interacting genes:
AFTPH
APP
CBL
CD247
CDKN1A
CENPJ
CHAF1A
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
MRPS6
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
47 interacting genes:
ANP32A
ANP32B
ASF1A
ASF1B
BLM
CBX1
CBX5
CDC7
CDK2
CHAF1B
CREBBP
DBF4
DDX41
H3-4
H3C6
HMGB2
LZTR1
MBD1
MEI4
MSH6
NOTO
PABPC1
PAX6
PCBD2
PCNA
POU6F2
RBFOX2
REL
SERTAD1
SET
SPOP
STAT5B
SUMO1
SUMO2
SUMO3
TCERG1
TCF4
TRIB3
TRIM28
XRCC5
XRCC6
YWHAB
YWHAE
YWHAG
YWHAQ
ZNF408
ZNF620
Entrez ID
6777
10036
HPRD ID
05037
03148
Ensembl ID
ENSG00000173757
ENSG00000167670
Uniprot IDs
P51692
Q13111
PDB IDs
6MBW
6MBZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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