STAT1 and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		STAT1	SHANK1
Description		signal transducer and activator of transcription 1	SH3 and multiple ankyrin repeat domains 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Nuclear Receptor Binding Enzyme Binding CCR5 Chemokine Receptor Binding Histone Acetyltransferase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin-like Protein Ligase Binding Cadherin Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Defense Response Receptor Signaling Pathway Via JAK-STAT Response To Nutrient Blood Circulation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-alpha Production Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Renal Tubule Development Interleukin-27-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Organic Cyclic Compound Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation	Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 26394269) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		109 interacting genes: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CDC42 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MFSD6 MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT4 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467	22 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8
Entrez ID		6772	50944
HPRD ID		02777	05413
Ensembl ID		ENSG00000115415	ENSG00000161681
Uniprot IDs		P42224	H9KV90 Q9Y566
PDB IDs		1BF5 1YVL 2KA6 3WWT	6CPI 6YWZ 6YX0 6YX1 6YX2
Enriched GO Terms of Interacting Partners?
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