ST14 and PDGFC

Number of citations of the paper that reports this interaction (PubMedID 22035541)
22

Data Source:
BioGRID (enzymatic study)

		ST14	PDGFC
Description		ST14 transmembrane serine protease matriptase	platelet derived growth factor C
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity Growth Factor Receptor Binding
	Biological Process	Neural Tube Closure Proteolysis Keratinocyte Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching	Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Central Nervous System Development Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Embryonic Organ Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		Formation of the cornified envelope Formation of the cornified envelope
Drugs		Urokinase Benzamidine Camostat
Diseases
GWAS		Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)	Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 34074324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypospadias ( 25108383) Immature fraction of reticulocytes ( 32888494) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Monocyte count ( 32888494) Motor coordination ( 34177493) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF NFRKB NOTCH2 PDGFC PHB PLAU RAD51 RGS16 SPINT1 STK11 TGFB1	5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1
Entrez ID		6768	56034
HPRD ID		06005	10529
Ensembl ID		ENSG00000149418	ENSG00000145431
Uniprot IDs		Q9Y5Y6	Q9NRA1
PDB IDs		1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T
Enriched GO Terms of Interacting Partners?
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