SRPK1 and DUSP6

Number of citations of the paper that reports this interaction (PubMedID 23602568)
71

Data Source:
BioGRID (enzymatic study)

		SRPK1	DUSP6
Description		SRSF protein kinase 1	dual specificity phosphatase 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Spliceosomal Complex Assembly Protein Phosphorylation Chromosome Segregation RNA Splicing Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	MAPK Cascade Negative Regulation Of Protein Phosphorylation Response To Xenobiotic Stimulus Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways		Maturation of nucleoprotein	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		171 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PPIL3 PRM1 PRPF38A PTK2 PTPN2 RBM23 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2	20 interacting genes: AATK CHRNE ERBB4 GABRA5 GLA IGF1 LMTK2 LTK MAPK1 MAPK3 MDFI NFYB NTN4 ROR2 SRPK1 TEX11 TPO TTN TXK ZNF212
Entrez ID		6732	1848
HPRD ID		15992	04124
Ensembl ID		ENSG00000096063	ENSG00000139318
Uniprot IDs		Q96SB4	A0A024RBC1 Q16828 Q53GP9
PDB IDs		1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD	1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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