SREBF1 and MED24

Number of citations of the paper that reports this interaction (PubMedID 16799563)
177

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		SREBF1	MED24
Description		sterol regulatory element binding transcription factor 1	mediator complex subunit 24
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Lipid Localization Regulation Of Lipid Storage Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Protein Ubiquitination Histone Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Coffee consumption ( 31046077) Eosinophil counts ( 32888494) Hip index ( 34021172) Lymphocyte counts ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Asthma ( 31619474) Bipolar disorder ( 31043756) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 31152163) Mitochondrial DNA copy number ( 30704525) Neutrophil count ( 25096241 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic ductal adenocarcinoma ( 30541042) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) White blood cell count ( 22037903 32888494 20139978 21738480 28158719)
Interacting Genes		41 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MAPK7 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C	14 interacting genes: APP AR CTDP1 ESR1 ESR2 GSK3B HNF4A MED9 PPARA PPARG RPS6KA6 RXRA SREBF1 TNFSF11
Entrez ID		6720	9862
HPRD ID		01701	06107
Ensembl ID		ENSG00000072310	ENSG00000008838
Uniprot IDs		A8MTU8 B3KR77 P36956	F5GY88 O75448
PDB IDs		1AM9
Enriched GO Terms of Interacting Partners?
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