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SRC and MAPK3
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
2
Data Source:
BioGRID
(two hybrid)
SRC
MAPK3
Description
SRC proto-oncogene, non-receptor tyrosine kinase
mitogen-activated protein kinase 3
Image
GO Annotations
Cellular Component
Podosome
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosome
Late Endosome
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuron Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Signaling Receptor Binding
Insulin Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Phospholipase Activator Activity
Enzyme Binding
Kinase Binding
Heme Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Phospholipase Binding
Transmembrane Transporter Binding
Cadherin Binding
Ephrin Receptor Binding
ATPase Binding
Phosphoprotein Binding
BMP Receptor Binding
Growth Factor Receptor Binding
Connexin Binding
Scaffold Protein Binding
Phosphotyrosine Residue Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Biological Process
Primary Ovarian Follicle Growth
Positive Regulation Of Cytokine Production
Stimulatory C-type Lectin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Cell Cycle
Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Virus
Response To Acidic PH
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Protein Processing
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell-cell Adhesion
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Response To Nutrient Levels
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Negative Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To Insulin Stimulus
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Integrin Activation
Adherens Junction Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Dephosphorylation
Intracellular Signal Transduction
Entry Of Bacterium Into Host Cell
Osteoclast Development
Cellular Response To Platelet-derived Growth Factor Stimulus
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Odontogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Stress Fiber Assembly
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Transcytosis
Innate Immune Response
Regulation Of Bone Resorption
Bone Resorption
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Oogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Progesterone Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Transport
Response To Mineralocorticoid
Response To Electrical Stimulus
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitochondrial Depolarization
Negative Regulation Of Telomerase Activity
Uterus Development
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cell Projection Assembly
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Progesterone Stimulus
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Fluid Shear Stress
Positive Regulation Of Podosome Assembly
Positive Regulation Of Protein Serine/threonine Kinase Activity
Angiotensin-activated Signaling Pathway Involved In Heart Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Cell-cell Adhesion
Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Ovarian Follicle Development
Positive Regulation Of Lamellipodium Morphogenesis
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Anoikis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Caveolin-mediated Endocytosis
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Aging
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Positive Regulation Of Macrophage Proliferation
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
Pathways
Signaling by ERBB2
Nuclear signaling by ERBB4
Downregulation of ERBB4 signaling
PIP3 activates AKT signaling
GAB1 signalosome
Downstream signal transduction
Constitutive Signaling by Aberrant PI3K in Cancer
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
DCC mediated attractive signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Regulation of commissural axon pathfinding by SLIT and ROBO
RAF activation
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PTK2 signaling
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of RUNX1 Expression and Activity
RUNX2 regulates osteoblast differentiation
Regulation of RUNX3 expression and activity
Extra-nuclear estrogen signaling
RHOU GTPase cycle
Activated NTRK2 signals through FYN
Activated NTRK3 signals through PI3K
Activated NTRK3 signals through PI3K
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Drugs
Dasatinib
RU84687
RU79256
N6-Benzyl Adenosine-5'-Diphosphate
RU85493
RU78262
Phosphonotyrosine
Malonic acid
RU83876
RU90395
RU79072
RU78783
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
PASBN
2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid
PAS219
DPI59
RU82197
Phenylphosphate
RU78300
RU79073
RU82209
ISO24
RU85053
RU78299
Oxalic Acid
RU78191
Citric acid
Paratoulene phosphate
4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
Purvalanol A
XL228
Tirbanibulin
Bosutinib
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
PD-168393
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
PP-121
1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
Ponatinib
Nintedanib
Fostamatinib
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Diseases
GWAS
Retinopathy in non-diabetics (
23393555
)
Rheumatoid arthritis (
30891314
)
Squamous cell carcinoma (
26908436
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
310 interacting genes:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
AFAP1
AFAP1L2
AGAP1
AKT1
ALDOB
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARR3
ASAP1
ATG9A
ATP2B4
AXL
BAAT
BARD1
BCAR1
BCCIP
BCR
BMX
CA3
CASP8
CAV1
CAV2
CBL
CBLC
CCDC180
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25A
CDC37
CDCP1
CDH5
CDK1
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
COASY
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTSV
CTTN
CUL4B
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
DPYD
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
EMD
ENO1
ENPP7
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESR1
ESR2
ETS1
ETS2
EVL
FANCC
FARP2
FASLG
FBP2
FBXO5
FGR
FHIT
FLNA
FLT3
FMR1
FOXO1
FRS2
FYB1
FZR1
GAB1
GAB2
GAB3
GALNT12
GFAP
GIT1
GJA1
GJB1
GRB10
GRB2
GRIN2A
GRIN2B
GRK2
GTF2I
GUCY2C
HDAC3
HEMGN
HLA-A
HLA-B
HNF1A
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAP2K1
MAPK15
MAPK3
MAPK8IP3
MAPRE1
MAPT
MATK
MDM2
MED28
MET
MICAL1
MPZL1
MST1R
MT-ND2
MUC1
MYLK
NANS
NCOA6
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1I2
NR1I3
NR3C1
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PI3
PIK3R1
PIK3R3
PIP5K1C
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PLTP
PPARD
PPARGC1B
PPP2CB
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PROM1
PTK2
PTK2B
PTPA
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRC
PTPRE
PTPRT
PXN
RACK1
RAF1
RARA
RASA1
RASGRF1
RET
RGS16
RPL10
RPS6KA3
RPS6KB1
RPS6KB2
RXRA
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCE1
SNCA
SOCS1
SORBS1
SPTAN1
SRCIN1
SRF
SRPK2
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
STX17
SYK
SYN1
TAMALIN
TERT
THRA
THRB
TIAM1
TMPO
TNFRSF11A
TNFRSF1A
TNK2
TP53
TRAF1
TRAF3
TRAF6
TRAT1
TRIM50
TRIM7
TRIP10
TRIP6
TRMO
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
XPA
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
ZNF189
ZNF687
187 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BUB1
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
DAPK1
DCC
DCP1A
DCP2
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
Entrez ID
6714
5595
HPRD ID
01819
03479
Ensembl ID
ENSG00000197122
ENSG00000102882
Uniprot IDs
P12931
L7RXH5
P27361
Q9BWJ1
PDB IDs
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
3ZMP
3ZMQ
4F59
4F5A
4F5B
4HXJ
4K11
4MXO
4MXX
4MXY
4MXZ
6ATE
6C4S
6E6E
6EHJ
2ZOQ
4QTB
6GES
Enriched GO Terms of Interacting Partners
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