SP3 and PAK6

		SP3	PAK6
Description		Sp3 transcription factor	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Transcription Repressor Complex Protein-DNA Complex	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways		SUMOylation of transcription factors	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 NKX3-1 PAK6 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A	28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1
Entrez ID		6670	56924
HPRD ID		03483	06426
Ensembl ID		ENSG00000172845	ENSG00000137843
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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