SP1 and VEGFA

Number of citations of the paper that reports this interaction (PubMedID 15342781)
67

Data Source:
BioGRID (pull down)

		SP1	VEGFA
Description		Sp1 transcription factor	vascular endothelial growth factor A
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex	Extracellular Region Extracellular Space Cytoplasm Adherens Junction Cell Surface Membrane Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity Extracellular Matrix Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation By Host Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Nervous System Development Mesoderm Development Lactation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitric Oxide Mediated Signal Transduction Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Surfactant Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Camera-type Eye Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cellular Component Movement Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Development Primitive Erythrocyte Differentiation Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Vascular Wound Healing Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Motor Neuron Migration Cellular Stress Response To Acid Chemical Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Adherens Junction Organization Positive Regulation Of Protein Kinase D Signaling Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression	Platelet degranulation Regulation of gene expression by Hypoxia-inducible Factor Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization Interleukin-4 and Interleukin-13 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs			Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pidolic acid Pegaptanib Vandetanib ABT-510 Veglin Denibulin SNS-032 Bevasiranib Dalteparin Aflibercept Chondroitin sulfate Foreskin keratinocyte (neonatal) Brolucizumab Faricimab
Diseases
GWAS		Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494)	Adiponectin levels ( 22479202) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 21665990) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 29875488) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body shape index ( 34021172) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778 33020668) Coronary heart disease ( 22319020) Creatinine levels ( 31015462 29124443 29403010) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Diastolic blood pressure ( 30224653) Early age-related macular degeneration ( 32843070) Estimated glomerular filtration rate ( 31015462 29124443 30604766) Fasting glucose change (short-term) ( 31263163) Fasting insulin ( 34059833) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hyperthyroidism ( 30367059) Hyperuricemia ( 29124443) Hypothyroidism ( 27182965) Immature fraction of reticulocytes ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Interleukin-10 levels ( 27989323) Interleukin-12p70 levels ( 27989323) Interleukin-13 levels ( 27989323) Interleukin-7 levels ( 27989323) Iron status biomarkers (ferritin levels) ( 33536631) Kidney volume ( 34128465) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Prostate-specific antigen levels ( 28139693) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum uric acid levels ( 30993211 29124443) Sexual dimorphism in anthropometric traits ( 23754948) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Triglyceride levels ( 32203549 28334899 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943) Type 2 diabetes ( 18372903 24509480 30054458 29358691 30297969) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31630189) Vascular endothelial growth factor levels ( 26910538 27989323 31217265) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500) White blood cell count ( 27863252)
Interacting Genes		152 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 ENDOU EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 GRIN1 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HNRNPA1 HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NEPRO NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RAPGEF3 RARA RB1 RBBP4 RBL1 REG1A REL RELA RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 USP39 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB7A	37 interacting genes: ADAMTS1 AKT1 CCN2 CRYAB ELAVL1 EPHB2 FLT1 FN1 GJB1 GPC1 HIF1A HNRNPD IGFBP7 KDR LYVE1 MDM2 NRP1 NRP2 PGF PRRG4 SEMA3F SLC16A2 SLC35C2 SP1 SP3 SPARC TFAP2A TFAP2B TMEM237 TNXB U2AF1 UBIAD1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID		6667	7422
HPRD ID		01796	01889
Ensembl ID		ENSG00000185591	ENSG00000112715
Uniprot IDs		P08047	A0A024RD33 A0A024RD37 A0A0Y0IMM4 A2A2V4 P15692
PDB IDs		1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89 6BFT 6D3O 6T9D 6V7K 7LL8 7LL9
Enriched GO Terms of Interacting Partners?
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