SOX4 and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
28

Data Source:
BioGRID (pull down)

		SOX4	RHOU
Description		SRY-box transcription factor 4	ras homolog family member U
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Golgi Membrane Podosome Cytosol Plasma Membrane Focal Adhesion Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Skeletal System Development Neural Tube Formation Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Ventricle Formation Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glial Cell Proliferation Spinal Cord Development Spinal Cord Motor Neuron Differentiation Glial Cell Development Cell Differentiation T Cell Differentiation Endocrine Pancreas Development Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Protein Stabilization Limb Bud Formation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of N-terminal Peptidyl-lysine Acetylation	Endocytosis Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Deactivation of the beta-catenin transactivating complex	Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Aging ( 22773346) Basal cell carcinoma ( 33549134 24403052 25855136 27539887 18849993) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	128 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 ARNTL AS3MT ATP5MG ATP6AP1 BDNF BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A ESYT1 FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 MARCKS ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIV2L SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		6659	58480
HPRD ID		01695	06965
Ensembl ID		ENSG00000124766	ENSG00000116574
Uniprot IDs		Q06945	A0A024R3Q7 Q7L0Q8
PDB IDs			2Q3H
Enriched GO Terms of Interacting Partners?
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