SOS2 and SNX9

Number of citations of the paper that reports this interaction (PubMedID 14679214)
76

Data Source:
HPRD (in vivo, in vitro)

		SOS2	SNX9
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	sorting nexin 9
Image
GO Annotations	Cellular Component	Cytosol	Ruffle Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Cuticular Plate Extracellular Exosome
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding
	Biological Process	B Cell Homeostasis Small GTPase Mediated Signal Transduction Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Catalytic Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Pro-B Cell Differentiation	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)	Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)
Interacting Genes		17 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	23 interacting genes: ADAM15 ADAM9 AP1G1 CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL
Entrez ID		6655	51429
HPRD ID		03149	12072
Ensembl ID		ENSG00000100485	ENSG00000130340
Uniprot IDs		Q07890	Q9Y5X1
PDB IDs		6EIE	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
Enriched GO Terms of Interacting Partners?
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