BNIP3 and SPACA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BNIP3	SPACA1
Description		BCL2 interacting protein 3	sperm acrosome associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Postsynaptic Density Dendrite Integral Component Of Mitochondrial Outer Membrane Mitochondrial Membrane	Inner Acrosomal Membrane Acrosomal Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding	Protein Binding
	Biological Process	Autophagy Of Mitochondrion Response To Hypoxia Apoptotic Process Cell Death Response To Bacterium Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Necrotic Cell Death Positive Regulation Of Macroautophagy Cerebral Cortex Development Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Response To Axon Injury Oligodendrocyte Differentiation Brown Fat Cell Differentiation Neuron Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Defense Response To Virus Response To Hyperoxia Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxygen-glucose Deprivation Mitochondrial Outer Membrane Permeabilization Granzyme-mediated Programmed Cell Death Signaling Pathway Toxin Transport Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Reactive Oxygen Species Metabolic Process	Acrosome Assembly
Pathways
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolite levels ( 23823483)	Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		71 interacting genes: AGTR1 AMIGO1 ARL13B BCL2 BCL2L1 BCL2L2 BIK BNIP2 BNIP3L CD3E CD47 CLDN9 CLEC7A CLN8 CMTM5 CREB3 CREB3L1 EBAG9 EBP ELOVL4 ERGIC3 FAM209A FAM241B FATE1 FFAR2 FXYD6-FXYD2 GPR152 GPR37 GPR42 HIF1A HIVEP1 HPN HTR2B IFNGR2 JAGN1 KTN1 LDLRAD1 LMNA MALL MAP1LC3B MFSD14B MS4A3 NCBP1 OPA1 PLP2 PPTC7 REEP2 RHEB RNASEK RNF24 RPRM SCN3B SEC22A SEC23A SLC31A2 SLC35B1 SLC6A17 SMIM3 SPACA1 TGM2 TLCD4 TM4SF18 TMEM101 TMEM106C TMEM11 TMEM205 TMPRSS2 TMX2 TNMD TUBGCP2 ZDHHC15	25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47
Entrez ID		664	81833
HPRD ID		04482	15419
Ensembl ID			ENSG00000118434
Uniprot IDs		Q12983 Q6NVY4	Q9HBV2
PDB IDs		2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?
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