SNRPA and METTL13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SNRPA	METTL13
Description		small nuclear ribonucleoprotein polypeptide A	methyltransferase 13, eEF1A lysine and N-terminal methyltransferase
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U1 SnRNP	Nucleus Cytoplasm Mitochondrion
	Molecular Function	RNA Binding Protein Binding U1 SnRNA Binding Identical Protein Binding	Protein Binding Methyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome	Negative Regulation Of Transcription By RNA Polymerase II Methylation Negative Regulation Of Cell Cycle G1/S Phase Transition
Pathways		mRNA Splicing - Major Pathway
Drugs		Malonic acid
Diseases
GWAS		Blood protein levels ( 28240269) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 27863252) melanoma-derived growth regulatory protein levels ( 25147954) Post bronchodilator FEV1 ( 26634245)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Diffusing capacity of carbon monoxide ( 30694715) Platelet distribution width ( 32888494)
Interacting Genes		54 interacting genes: CDKN2A CHTOP CIRBP DAPK1 DAZAP1 DDIT4L DDX39B ENOX2 EP300 FBXO7 FUBP1 GABPB1 GIGYF1 HNRNPK IL7R LENG8 LHX4 LNX1 MBNL2 METTL13 MRPL15 MTUS2 NDUFAF3 OTX2 PAPOLA PCBP1 PCBP2 PCBP3 PTBP1 PTBP2 QKI RASAL3 RBM11 RBM3 RBM42 RBM4B RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 SDCBP SFPQ SMAD5 SNRPA1 TIAL1 TLE5 TNFAIP8L1 TRIM27 TRIR U2AF2 UBC WBP4 ZCCHC13	5 interacting genes: EDEM3 SNRPA THAP1 TRAF2 VPS52
Entrez ID		6626	51603
HPRD ID		01658	13821
Ensembl ID		ENSG00000077312	ENSG00000010165
Uniprot IDs		P09012	C4B4C6 Q8N6R0
PDB IDs		1AUD 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 3UTR 4C4W 4PR6 4PRF 4W90 4W92 4YB1 5DDO 5DDP 5DDQ 5DDR 5FJ4 6LAS 6LAU 6LAX 6LAZ 6QX9 6SQN 6SQQ 6SQT 6SQV 6SR7 6XH0 6XH1 6XH2 6XH3 7AEP 7B0Y 7D7V	5WCJ
Enriched GO Terms of Interacting Partners?
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