SUMO3 and TDG

Number of citations of the paper that reports this interaction (PubMedID 11889051)
135

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		SUMO3	TDG
Description		small ubiquitin like modifier 3	thymine DNA glycosylase
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Uracil DNA N-glycosylase Activity Protein Binding ATP Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding Protein Homodimerization Activity Protein Self-association G/U Mismatch-specific Uracil-DNA Glycosylase Activity DNA-binding Transcription Factor Binding
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Chromatin Organization Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Depyrimidination Regulation Of Embryonic Development DNA Demethylation Regulation Of DNA N-glycosylase Activity
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Delirium ( 29631748)	Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		55 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TRAPPC10 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496	36 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD9A RXRA SERBP1 SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC
Entrez ID		6612	6996
HPRD ID		03754	03251
Ensembl ID		ENSG00000184900	ENSG00000139372
Uniprot IDs		P55854	B4DI29 B4E127 Q13569
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ	1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?