SMS and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SMS	MAPKAPK3
Description		spermine synthase	MAPK activated protein kinase 3
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Spermine Synthase Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Metabolism of polyamines	p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs		Spermine	2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS			Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: EZH2 LARP7 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	22 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		6611	7867
HPRD ID		02115	03678
Ensembl ID		ENSG00000102172	ENSG00000114738
Uniprot IDs		P52788	A0A024R2W7 Q16644
PDB IDs		3C6K 3C6M	3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?
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