SMARCC1 and RELB

Number of citations of the paper that reports this interaction (PubMedID 14743216)
321

Data Source:
HPRD (in vitro)

		SMARCC1	RELB
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	RELB proto-oncogene, NF-kB subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Chromatin Nucleus Nucleoplasm Centrosome Cytosol Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Gene Expression Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Cellular Response To Osmotic Stress
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		54 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PRMT5 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 STT3B TAF15 TRIM42 UFSP1 VGLL3 ZNF581	25 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11
Entrez ID		6599	5971
HPRD ID		03435	06886
Ensembl ID		ENSG00000173473	ENSG00000104856
Uniprot IDs		Q58EY4 Q92922	D6R992 Q01201
PDB IDs		2YUS 5GJK 6KZ7
Enriched GO Terms of Interacting Partners?
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