PLEKHA3 and DOK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHA3	DOK3
Description		pleckstrin homology domain containing A3	docking protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Membrane	Cytoplasm Plasma Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Protein Binding
	Biological Process	Biological_process Ceramide Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane	Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B PRKRA RNMT SH2B2 TCL1B	31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1
Entrez ID		65977	79930
HPRD ID		09688	16834
Ensembl ID		ENSG00000116095	ENSG00000146094
Uniprot IDs		Q9HB20	A0A024R7M5 A0A6M4C8X9 D6RAM3 Q7L591
PDB IDs		2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?
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