SLC22A1 and KRTCAP2

Number of citations of the paper that reports this interaction (PubMedID 31318583)
3

Data Source:
BioGRID (protein complementation assay)

		SLC22A1	KRTCAP2
Description		solute carrier family 22 member 1	keratinocyte associated protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Presynapse	Oligosaccharyltransferase Complex Integral Component Of Membrane
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity	Enzyme Activator Activity
	Biological Process	Neurotransmitter Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Purine-containing Compound Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Dopamine Uptake Cation Transmembrane Transport Transport Across Blood-brain Barrier Acetate Ester Transport Toxin Transport Xenobiotic Transport Across Blood-brain Barrier	Protein N-linked Glycosylation Protein N-linked Glycosylation Via Arginine Regulation Of Catalytic Activity
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 26034056 21743057) Serum metabolite levels ( 33031748 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dentures ( 31235808) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 30804560) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Peak expiratory flow ( 30804560) Perceived intensity of sucrose ( 31005972) PR interval ( 30046033 32439900) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		30 interacting genes: ALDOA ARID5B CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM GRM3 KRTCAP2 LAPTM4A LAPTM4B MUC1 OS9 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	5 interacting genes: APP CREB3 SHD SLC22A1 SLC22A2
Entrez ID		6580	200185
HPRD ID		04007	17253
Ensembl ID		ENSG00000175003	ENSG00000163463
Uniprot IDs		O15245	Q8N6L1
PDB IDs
Enriched GO Terms of Interacting Partners?
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