BMPR1B and SLC39A8

		BMPR1B	SLC39A8
Description		bone morphogenetic protein receptor type 1B	solute carrier family 39 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Phosphatase Activator Activity BMP Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Metal Ion Binding BMP Receptor Activity Transcription Regulator Activator Activity	Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Anion:cation Symporter Activity Selenite:proton Symporter Activity Zinc:bicarbonate Symporter Activity
	Biological Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein N-linked Glycosylation Arginine Metabolic Process Cobalt Ion Transport Zinc Ion Transport Cellular Cadmium Ion Homeostasis Cellular Zinc Ion Homeostasis Inorganic Anion Transport Bicarbonate Transport Cellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport
Pathways		Signaling by BMP	Zinc influx into cells by the SLC39 gene family
Drugs		Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)	Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anterior thalamic nuclei volume ( 34006833) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 29381148 26961502 25673413 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hypertension ( 31879980 21909115) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) Lateral thalamic nuclei volume ( 34006833) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 33830993 31194737) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 32888494 27863252) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein level ( 29403010) Shoulder impingement or rotator cuff tear ( 33482370) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549 32154731) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		65 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SLC39A8 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	6 interacting genes: ADH6 BMPR1B CXXC4 PTGER4 SMARCAD1 STPG2
Entrez ID		658	64116
HPRD ID		04457	12286
Ensembl ID		ENSG00000138696	ENSG00000138821
Uniprot IDs		A8KAE3 O00238	A0A024RDG0 Q9C0K1
PDB IDs		3MDY
Enriched GO Terms of Interacting Partners?
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