WNK3 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 23387299)
74

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method)

		WNK3	KLHL3
Description		WNK lysine deficient protein kinase 3	kelch like family member 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Phosphorylation Cell Volume Homeostasis Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Stimuli-sensing channels	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 28552196)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		4 interacting genes: KLHL3 LBX1 REL TSC22D2	18 interacting genes: ACSL6 AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK3 WNK4
Entrez ID		65267	26249
HPRD ID		02289	09011
Ensembl ID		ENSG00000196632	ENSG00000146021
Uniprot IDs		Q9BYP7	Q9UH77
PDB IDs		5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C	4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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