SIM1 and FOXO3

		SIM1	FOXO3
Description		SIM bHLH transcription factor 1	forkhead box O3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Aging Response To Xenobiotic Stimulus Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brain Morphogenesis Response To Fatty Acid Cellular Response To Glucose Stimulus Cellular Response To Corticosterone Stimulus Cellular Response To Hypoxia Response To Dexamethasone Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus Response To Water-immersion Restraint Stress Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Creatinine levels ( 29403010) Erectile dysfunction ( 30297428) Estimated glomerular filtration rate ( 31152163) Gait speed in old age ( 28077804) Glomerular filtration rate ( 29403010) Iris color (L* coordinate) ( 30895295) Irritable mood ( 29500382) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 27479909) Menarche (age at onset) ( 25231870) Neurociticism ( 29500382) Neuroticism ( 29255261) Sociability score ( 34054130) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area ( 32963231) Cortical volume ( 32963231) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 32888494 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Thalamus volume ( 34006833) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		4 interacting genes: ARNT ARNT2 FOXO3 HSP90AA1	31 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 GPR6 HDAC2 IKBKB MAPK1 MAPK6 MDM2 NR1H2 NR1H3 PRDM13 PTPA SGK1 SIM1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ
Entrez ID		6492	2309
HPRD ID		07049	04061
Ensembl ID		ENSG00000112246	ENSG00000118689
Uniprot IDs		P81133	O43524
PDB IDs			2K86 2LQH 2LQI 2UZK 6MNL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?