AGXT2 and CYP2E1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		AGXT2	CYP2E1
Description		alanine--glyoxylate aminotransferase 2	cytochrome P450 family 2 subfamily E member 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Golgi Membrane Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Alanine-glyoxylate Transaminase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Hsp90 Protein Binding Aromatase Activity
	Biological Process	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Positive Regulation Of Nitric Oxide Biosynthetic Process	Lipid Hydroxylation Organic Acid Metabolic Process Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process Response To Ethanol Heterocycle Metabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Pyrimidine catabolism	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs		Pyridoxal phosphate Pyruvic acid Glycine Alanine	Diacerein
Diseases
GWAS		Metabolite levels ( 21931564) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Symmetrical dimethylarginine levels ( 25245031 24159190) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414) Urinary metabolites (H-NMR features) ( 24586186)	Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		2 interacting genes: ALDOB CYP2E1	15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		64902	1571
HPRD ID		10638	11813
Ensembl ID		ENSG00000113492	ENSG00000130649
Uniprot IDs		Q9BYV1	P05181
PDB IDs			3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?
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