SIAH2 and DCC

Number of citations of the paper that reports this interaction (PubMedID 9858595)
78

Data Source:
HPRD (in vitro)

		SIAH2	DCC
Description		siah E3 ubiquitin protein ligase 2	DCC netrin 1 receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Small GTPase Mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Neuron Migration Apoptotic Process Axonogenesis Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Dendrite Development
Pathways		Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)	Age at first sexual intercourse ( 27089180 34211149) Alcoholism (alcohol use disorder factor score) ( 21529783) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 33859377 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Homeostasis model assessment of insulin resistance ( 33381925) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 33830993 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 33169155 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		44 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1	38 interacting genes: ADORA2B AFDN-DT ALDOB ANP32B APPL1 AR ARG2 BARD1 CASP3 CASP9 CORO2A CTSV FBP1 FECH GPI HEMGN MAPK3 MAZ NARS1 NCK1 NSDHL NTN1 PITPNA POLR2E PTK2 RASA1 RPL5 SERPINB2 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TNNI1 TRMO TSTD2 TULP4
Entrez ID		6478	1630
HPRD ID		03737	00391
Ensembl ID		ENSG00000181788	ENSG00000187323
Uniprot IDs		O43255	P43146 Q49AK4
PDB IDs		5H9M	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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