CLEC7A and SPINT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLEC7A	SPINT1
Description		C-type lectin domain containing 7A	serine peptidase inhibitor, Kunitz type 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling	MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		47 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		64581	6692
HPRD ID		08396	05494
Ensembl ID		ENSG00000172243	ENSG00000166145
Uniprot IDs		A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2	O43278
PDB IDs			1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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