KLHL25 and ACLY

Number of citations of the paper that reports this interaction (PubMedID 27664236)
20

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		KLHL25	ACLY
Description		kelch like family member 25	ATP citrate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function		ATP Citrate Synthase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs			Bempedoic acid
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		2 interacting genes: ACLY SEC11A	9 interacting genes: APP CDKN2A CUL3 DDIAS FXR1 GSK3B HGS KLHL25 PRKACA
Entrez ID		64410	47
HPRD ID		07780	00155
Ensembl ID		ENSG00000183655	ENSG00000131473
Uniprot IDs		Q9H0H3	A0A024R1T9 A0A024R1Y2 P53396 Q4LE36
PDB IDs			3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 7LLA
Enriched GO Terms of Interacting Partners?
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