SFTPC and SEC61G

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SFTPC	SEC61G
Description		surfactant protein C	SEC61 translocon subunit gamma
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Cytosol Membrane Integral Component Of Membrane Ssh1 Translocon Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Respiratory Gaseous Exchange By Respiratory System	Posttranslational Protein Targeting To Membrane, Translocation Protein Targeting To ER
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51
Entrez ID		6440	23480
HPRD ID		01520	15318
Ensembl ID		ENSG00000168484	ENSG00000132432
Uniprot IDs		A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686	A0A024QYZ0 P60059
PDB IDs		2YAD	6W6L
Enriched GO Terms of Interacting Partners?
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