NSD1 and NR2F1

Number of citations of the paper that reports this interaction (PubMedID 23975195)
8

Data Source:
BioGRID (two hybrid)

		NSD1	NR2F1
Description		nuclear receptor binding SET domain protein 1	nuclear receptor subfamily 2 group F member 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Signal Transduction Nervous System Development Negative Regulation Of Neuron Projection Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		PKMTs methylate histone lysines	Nuclear Receptor transcription pathway
Drugs			beta-Naphthoflavone
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lymphocyte counts ( 32888494) Narrowest width of the femoral neck ( 30888730) Neutrophil count ( 32888494) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Leftâ€“right brain asymmetry ( 33723403) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		41 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G KRTAP6-2 MDFI NPR3 NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG PRKCD RARA RING1 RORA RORB RTN4 RXRA SNORD3A SNRPF THRA THRB TNFRSF21 VDR ZNF496	24 interacting genes: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 GTF2B HNF4A ISL1 MAP6 MCPH1 MEF2C NCOA1 NCOA2 NCOA3 NCOR2 NSD1 PFDN1 PHB2 POU2F2 RXRA SP1 THRA
Entrez ID		64324	7025
HPRD ID		09455	00584
Ensembl ID		ENSG00000165671	ENSG00000175745
Uniprot IDs		Q96L73 Q96MN8	P10589
PDB IDs		3OOI 6KQP 6KQQ	2EBL
Enriched GO Terms of Interacting Partners?
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