SCN3A and GET1

		SCN3A	GET1
Description		sodium voltage-gated channel alpha subunit 3	guided entry of tail-anchored proteins factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytoplasm Axon	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane GET Complex
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity	Protein Binding
	Biological Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Epilepsy ( 30531953) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CNTN1 GET1 LRP1 LRP2 LRP8 PRKCG	34 interacting genes: ABHD5 APOA2 APOL2 AQP1 BOC CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 GATD3 HMOX2 HTATIP2 ORMDL3 PDXK PLPP4 PTPN9 RASGRP3 RTP2 SCN3A SERP2 SLC35E3 SLC4A2 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42 TRAPPC10
Entrez ID		6328	7485
HPRD ID		01671	04224
Ensembl ID		ENSG00000153253	ENSG00000182093
Uniprot IDs		A0A590UJH3 Q9C007 Q9NY46	O00258
PDB IDs			6SO5
Enriched GO Terms of Interacting Partners?
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