SCN1A and NAB2

		SCN1A	NAB2
Description		sodium voltage-gated channel alpha subunit 1	NGFI-A binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Plasma Membrane Nuclear Body Z Disc Axon	Nucleus Nucleoplasm
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential	Endochondral Ossification Regulation Of Transcription, DNA-templated Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Positive Regulation Of Tau-protein Kinase Activity
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Phenacemide Phenazopyridine Nitrazepam Permethrin Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Epilepsy ( 25087078 30531953) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953 22949513) Mesial temporal lobe epilepsy with hippocampal sclerosis ( 24014518) Whole brain grey matter density ( 31530798)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31959851 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: CALM1 NAB2 PSEN1 SNTA1	87 interacting genes: ANK3 ANKRD11 APH1B CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM9A GCC1 GOLGA6L9 HOXA10 HRH1 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 LRP1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 MYO1A NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RDH5 RFC5 RINT1 SCN1A SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZBED8 ZMAT2 ZMYND12 ZMYND19 ZNF417
Entrez ID		6323	4665
HPRD ID		01669	03854
Ensembl ID		ENSG00000144285	ENSG00000166886
Uniprot IDs		P35498	Q15742
PDB IDs
Enriched GO Terms of Interacting Partners?
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