RPS6KA3 and ILKAP

Number of citations of the paper that reports this interaction (PubMedID 29371914)
6

Data Source:
BioGRID (enzymatic study)

		RPS6KA3	ILKAP
Description		ribosomal protein S6 kinase A3	ILK associated serine/threonine phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Nucleus Nucleoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity	Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Dephosphorylation
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Refractive error ( 32231278)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 27863252)
Interacting Genes		41 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 DPYD EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1	23 interacting genes: AATK CHEK1 EGFR EPHA2 EPHA3 ERBB2 ERBB3 ERBB4 FBXO7 HGS IGF1R ILK KDR KIT LMTK2 MAPK14 MUSK OGT PTK7 ROR1 ROR2 RPS6KA3 TEK
Entrez ID		6197	80895
HPRD ID		02092	17147
Ensembl ID		ENSG00000177189	ENSG00000132323
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	Q9H0C8
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
Enriched GO Terms of Interacting Partners?
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