RPLP1 and MPC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPLP1	MPC2
Description		ribosomal protein lateral stalk subunit P1	mitochondrial pyruvate carrier 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome	Nucleus Mitochondrion Integral Component Of Mitochondrial Inner Membrane
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Kinase Activator Activity Ribonucleoprotein Complex Binding	Protein Binding Identical Protein Binding Pyruvate Transmembrane Transporter Activity
	Biological Process	Cytoplasmic Translation Translation Translational Elongation Activation Of Protein Kinase Activity	Mitochondrial Pyruvate Transmembrane Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Pyruvate metabolism
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Male-pattern baldness ( 27182965) Non-response to citalopram or escitalopram and depression ( 27622933)
Interacting Genes		36 interacting genes: ANKRD13B ARF6 ASCC2 ATP5MF BRD7 C11orf58 C15orf39 CDIPT CDK2AP2 CLIC1 CSNK2A1 EEF1A1 GEMIN7 GSK3B LRIF1 MAP1LC3B MPC2 NSF NUDT21 NUDT3 PDCD4 PFDN1 PPP2CB PTN RCHY1 RPA2 RPLP2 RPS6KA6 SAT1 SGO1 SUOX TAB1 TPT1 TUBB2A UBE2D3 XRCC6	13 interacting genes: APOC1 CIDEB DIABLO MICOS10 MPC1 NEAT1 RHBDD2 RPLP1 SNX1 SPG21 SYT16 TEX44 TIMM17B
Entrez ID		6176	25874
HPRD ID		01611	08525
Ensembl ID		ENSG00000137818	ENSG00000143158
Uniprot IDs		A0A024R608 P05386	A0A024R8Z5 O95563
PDB IDs		2LBF 4BEH 4V6X
Enriched GO Terms of Interacting Partners?
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