RPA3 and RFWD3

Number of citations of the paper that reports this interaction (PubMedID 24126761)
87

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		RPA3	RFWD3
Description		replication protein A3	ring finger and WD repeat domain 3
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GO Annotations	Cellular Component	Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding	P53 Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair Nucleotide-excision Repair Mismatch Repair Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Chromosome Breakage Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases
GWAS		Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Estimated glomerular filtration rate ( 29779033) Insulin-like growth factors ( 21216879) Interstitial lung diseases in rheumatoid arthritis ( 32737115) Intraocular pressure ( 30591961) Serum creatinine levels ( 29779033) Urate levels in obese individuals ( 25811787)	Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		11 interacting genes: ATRIP CDC5L ERCC1 MAD1L1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4	15 interacting genes: APP ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		6119	55159
HPRD ID		01567	07678
Ensembl ID		ENSG00000106399	ENSG00000168411
Uniprot IDs		A4D105 P35244	Q6PCD5
PDB IDs		1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF	6CVZ
Enriched GO Terms of Interacting Partners?
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