BCL2A1 and BOK

Number of citations of the paper that reports this interaction (PubMedID 9356461)
77

Data Source:
HPRD (two hybrid)

		BCL2A1	BOK
Description		BCL2 related protein A1	BCL2 family apoptosis regulator BOK
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Early Endosome Membrane Mitochondrial Membrane Trans-Golgi Network Membrane Cis-Golgi Network Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding	Signaling Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cerebral Cortex Development Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Autophagy Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Protein Complex Oligomerization Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	Brain structure ( 20171287) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Planum temporale asymmetry index ( 31887566) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NR4A1 PMAIP1 SLC9A3R1	3 interacting genes: BCL2A1 MCL1 NOA1
Entrez ID		597	666
HPRD ID		03034	05657
Ensembl ID		ENSG00000140379	ENSG00000176720
Uniprot IDs		Q16548	A0A024R4A8 A0A481T0W6 A0A4D6NU76 Q9UMX3
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4	6CKV
Enriched GO Terms of Interacting Partners?
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