BCL2 and RTN4

Number of citations of the paper that reports this interaction (PubMedID 11126360)
46

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		BCL2	RTN4
Description		BCL2 apoptosis regulator	reticulon 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Protein-containing Complex Myelin Sheath Pore Complex	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane
	Molecular Function	Protease Binding Protein Binding Channel Activity Channel Inhibitor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding DNA-binding Transcription Factor Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Ossification Ovarian Follicle Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response B Cell Homeostasis Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment Response To Ischemia Renal System Process Protein Dephosphorylation Melanin Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Humoral Immune Response Cellular Response To DNA Damage Stimulus Actin Filament Organization Axonogenesis Female Pregnancy Cell Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Radiation Response To Xenobiotic Stimulus Response To Toxic Substance Post-embryonic Development Response To Iron Ion Response To UV-B Response To Gamma Radiation Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cochlear Nucleus Development Gland Morphogenesis Regulation Of Transmembrane Transporter Activity Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Regulation Of Protein Localization Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Hydrogen Peroxide T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Spleen Development Thymus Development Digestive Tract Morphogenesis Oocyte Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Organic Substance Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Axonal growth inhibition (RHOA activation)
Drugs		Ibuprofen Paclitaxel Docetaxel Rasagiline Paclitaxel docosahexaenoic acid Apoptone Glycine betaine Eribulin Dexibuprofen Isosorbide Venetoclax Obatoclax Navitoclax
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301 34315874) Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index ( 28892062 25673413) Body mass index and fasting insulin (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Cardiac Troponin-T levels ( 23247143) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive hairiness ( 29895819) Fasting insulin ( 34059833) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Red blood cell count ( 32888494 27863252) Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase) ( 31465739) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 28869590) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte counts ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)
Interacting Genes		87 interacting genes: ATP2A2 BAD BAG1 BAG3 BAG4 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS FKBP8 HNRNPD HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPARA PPID PPP1CA PPP2CA PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RNF183 RRAS RTN4 SEPTIN4 SF1 SMN1 SOD1 SPHK2 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2 XIAP	55 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CGREF1 CHMP6 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C IPP LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 OGT PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		596	57142
HPRD ID		01045	07259
Ensembl ID		ENSG00000171791	ENSG00000115310
Uniprot IDs		A0A024R2B3 A0A024R2C4 A0A7I2V3S7 P10415	Q9NQC3
PDB IDs		1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX 5FCG 5JSN 5VAU 5VAX 5VAY 6GL8 6IWB 6O0K 6O0L 6O0M 6O0O 6O0P	2G31 2JV5
Enriched GO Terms of Interacting Partners?
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