RBL2 and BRF1

Number of citations of the paper that reports this interaction (PubMedID 10330166)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RBL2	BRF1
Description		RB transcriptional corepressor like 2	BRF1 RNA polymerase III transcription initiation factor subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA-templated Transcription, Initiation Transcription By RNA Polymerase III Transcription Initiation From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Positive Regulation Of Transcription By RNA Polymerase III Transcription Preinitiation Complex Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Huntington's disease progression ( 28642124) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC
Entrez ID		5934	2972
HPRD ID		01576	05361
Ensembl ID		ENSG00000103479	ENSG00000185024
Uniprot IDs		Q08999	A0A024R6P8 Q92994 V9HVY2
PDB IDs		4XI9 5C1D
Enriched GO Terms of Interacting Partners?
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