ACE2 and NTS

Number of citations of the paper that reports this interaction (PubMedID 11815627)
476

Data Source:
HPRD (in vitro)

		ACE2	NTS
Description		angiotensin converting enzyme 2	neurotensin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Membrane Raft Extracellular Exosome	Extracellular Region Transport Vesicle Intracellular Membrane-bounded Organelle Axon Terminus
	Molecular Function	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Identical Protein Binding	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Neuropeptide Signaling Pathway
Pathways		Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: AGT CALM1 CDSN DEFA5 DLEU2 GHRL MAST1 MAST2 NTS PARD3 PDZK1 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SLC6A19 SLC9A3R1 SLC9A3R2 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		59272	4922
HPRD ID		02274	08878
Ensembl ID		ENSG00000130234	ENSG00000133636
Uniprot IDs		Q9BYF1	P30990 Q6FH20
PDB IDs		1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DF4 7DMU 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F	2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7
Enriched GO Terms of Interacting Partners?
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