RALGDS and RRAS

Number of citations of the paper that reports this interaction (PubMedID 7809086)
72

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		RALGDS	RRAS
Description		ral guanine nucleotide dissociation stimulator	RAS related
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GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Plasma Membrane Focal Adhesion Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)
Interacting Genes		27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10	18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63
Entrez ID		5900	6237
HPRD ID		03371	01299
Ensembl ID		ENSG00000160271	ENSG00000126458
Uniprot IDs		Q12967 Q8N4Y1	A0A024QZF2 P10301
PDB IDs		1RAX 2B3A 2RGF 3KH0	2FN4
Enriched GO Terms of Interacting Partners?
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